Functioning gonadotropic adenoma
ORPHA:91348DiseaseAdult
Фенотипы (HPO)34
Облигатный (100%)1
HP:0011759Pituitary gonadotropic cell adenoma
Частый (30–79%)10
HP:0000140Abnormality of the menstrual cycle
HP:0000505Visual impairment
HP:0000789Infertility
HP:0000802Impotence
HP:0000830Anterior hypopituitarism
HP:0001123Visual field defect
HP:0012378Fatigue
HP:0030018Decreased female libido
HP:0030088Increased serum testosterone level
HP:0040086Abnormal prolactin level
Периодический (5–29%)23
HP:0000138Ovarian cyst
HP:0000141Amenorrhea
HP:0000238Hydrocephalus
HP:0000798Oligozoospermia
HP:0000823Delayed puberty
HP:0000824Decreased response to growth hormone stimulation test
HP:0000837Increased circulating gonadotropin level
HP:0000863Central diabetes insipidus
HP:0000871Panhypopituitarism
HP:0000938Osteopenia
HP:0000939Osteoporosis
HP:0001541Ascites
HP:0002050Macroorchidism, postpubertal
HP:0002315Headache
HP:0002625Deep venous thrombosis
HP:0002750Delayed skeletal maturation
HP:0008236Isosexual precocious puberty
HP:0008245Pituitary hypothyroidism
HP:0008675Enlarged polycystic ovaries
HP:0009888Abnormality of secondary sexual hair
HP:0011748Adrenocorticotropic hormone deficiency
HP:0012246Oculomotor nerve palsy
HP:0100829Galactorrhea
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)