Sheehan syndrome
ORPHA:91355Malformation syndromeAdult
Фенотипы (HPO)49
Очень частый (80–99%)7
HP:0000871Panhypopituitarism
HP:0000876Oligomenorrhea
HP:0008163Decreased circulating cortisol level
HP:0008240Secondary growth hormone deficiency
HP:0011735Adrenocorticotropin deficient adrenal insufficiency
HP:0011748Adrenocorticotropic hormone deficiency
HP:0012432Chronic fatigue
Частый (30–79%)23
HP:0030016Dyspareunia
HP:0030018Decreased female libido
HP:0000141Amenorrhea
HP:0000622Blurred vision
HP:0000802Impotence
HP:0000958Dry skin
HP:0000980Pallor
HP:0001278Orthostatic hypotension
HP:0001895Normochromic anemia
HP:0001943Hypoglycemia
HP:0002018Nausea
HP:0002215Sparse axillary hair
HP:0002225Sparse pubic hair
HP:0002315Headache
HP:0003158Hyposthenuria
HP:0003187Breast hypoplasia
HP:0007987Progressive visual field defects
HP:0008202Reduced circulating prolactin concentration
HP:0008213Gonadotropin deficiency
HP:0008214Decreased serum estradiol
HP:0008245Pituitary hypothyroidism
HP:0011734Central adrenal insufficiency
HP:0012504Abnormal size of pituitary gland
Периодический (5–29%)16
HP:0000407Sensorineural hearing impairment
HP:0000651Diplopia
HP:0000872Hashimoto thyroiditis
HP:0001324Muscle weakness
HP:0001513Obesity
HP:0001662Bradycardia
HP:0001962Palpitations
HP:0002019Constipation
HP:0002321Vertigo
HP:0002829Arthralgia
HP:0002902Hyponatremia
HP:0003493Antinuclear antibody positivity
HP:0004396Poor appetite
HP:0007041Chronic lymphocytic meningitis
HP:0025143Chills
HP:0030907Thunderclap headache
Очень редкий (1–4%)3
HP:0000709Psychosis
HP:0000863Central diabetes insipidus
HP:0001259Coma
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | Unknown | — | Worldwide | Class only |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)