Tubulointerstitial nephritis and uveitis syndrome
ORPHA:91500DiseaseMultigenic/multifactorialAdolescent, Adult, Childhood, Elderly
Фенотипы (HPO)53
Очень частый (80–99%)6
HP:0001970Tubulointerstitial nephritis
HP:0007813Nongranulomatous uveitis
HP:0025466Beta 2-microglobulinuria
HP:0032589Renal lymphocytic tubulitis
HP:0032590Renal neutrophilic tubulitis
HP:0032637Renal interstitial edema
Частый (30–79%)13
HP:0001085Papilledema
HP:0001824Weight loss
HP:0001945Fever
HP:0002907Microscopic hematuria
HP:0003259Elevated circulating creatinine concentration
HP:0012122Anterior uveitis
HP:0012123Posterior uveitis
HP:0012213Decreased glomerular filtration rate
HP:0012378Fatigue
HP:0012595Mild proteinuria
HP:0025337Red eye
HP:0100586Sterile pyuria
HP:0200026Ocular pain
Периодический (5–29%)31
HP:0000505Visual impairment
HP:0000518Cataract
HP:0000613Photophobia
HP:0000988Skin rash
HP:0001895Normochromic anemia
HP:0001897Normocytic anemia
HP:0001994Renal Fanconi syndrome
HP:0002027Abdominal pain
HP:0002039Anorexia
HP:0002829Arthralgia
HP:0003237Increased circulating IgG level
HP:0003326Myalgia
HP:0003355Aminoaciduria
HP:0003565Elevated erythrocyte sedimentation rate
HP:0004918Hyperchloremic metabolic acidosis
HP:0007902Vitreous hemorrhage
HP:0007906Ocular hypertension
HP:0008682Renal tubular epithelial necrosis
HP:0010702Increased circulating antibody level
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011484Posterior synechiae of the anterior chamber
HP:0011505Cystoid macular edema
HP:0011506Choroidal neovascularization
HP:0012121Panuveitis
HP:0012124Intermediate uveitis
HP:0025188Retinal vasculitis
HP:0030157Flank pain
HP:0031616Anterior chamber flare
HP:0031851Reduced hematocrit
HP:0040049Macular edema
HP:0100532Scleritis
Очень редкий (1–4%)3
HP:0007703Abnormality of retinal pigmentation
HP:0007777Chorioretinal scar
HP:0011525Iris nevus
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)