Immune-mediated thrombotic thrombocytopenic purpura
ORPHA:93585Clinical subtypeMultigenic/multifactorialAll ages
Фенотипы (HPO)41
Очень частый (80–99%)4
HP:0000979Purpura
HP:0001873Thrombocytopenia
HP:0001937Microangiopathic hemolytic anemia
HP:6000462Anti-ADAMTS13 antibody positivity
Частый (30–79%)25
HP:0000093Proteinuria
HP:0000790Hematuria
HP:0001250Seizure
HP:0001259Coma
HP:0001289Confusion
HP:0001297Stroke
HP:0001324Muscle weakness
HP:0001923Reticulocytosis
HP:0001945Fever
HP:0001981Schistocytosis
HP:0002014Diarrhea
HP:0002018Nausea
HP:0002027Abdominal pain
HP:0002094Dyspnea
HP:0002315Headache
HP:0002829Arthralgia
HP:0002904Hyperbilirubinemia
HP:0003326Myalgia
HP:0003419Low back pain
HP:0008282Unconjugated hyperbilirubinemia
HP:0012378Fatigue
HP:0020181Reduced haptoglobin level
HP:0025435Increased circulating lactate dehydrogenase concentration
HP:0033404Intestinal ischemia
HP:0410173Increased circulating troponin I concentration
Периодический (5–29%)12
HP:0000651Diplopia
HP:0001635Congestive heart failure
HP:0001645Sudden cardiac death
HP:0001658Myocardial infarction
HP:0001919Acute kidney injury
HP:0002381Aphasia
HP:0003115Abnormal EKG
HP:0003138Increased blood urea nitrogen
HP:0003259Elevated circulating creatinine concentration
HP:0011675Arrhythmia
HP:0030149Cardiogenic shock
HP:0100749Chest pain
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | — | Europe | Class only |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)