Neuroleptic malignant syndrome
ORPHA:94093DiseaseUnknownAll ages
Фенотипы (HPO)54
Очень частый (80–99%)6
HP:0000975Hyperhidrosis
HP:0001945Fever
HP:0002300Mutism
HP:0004372Reduced consciousness/confusion
HP:0007076Extrapyramidal muscular rigidity
HP:0012332Abnormal autonomic nervous system physiology
Частый (30–79%)11
HP:0000822Hypertension
HP:0001337Tremor
HP:0001649Tachycardia
HP:0001942Metabolic acidosis
HP:0001974Leukocytosis
HP:0002015Dysphagia
HP:0002307Drooling
HP:0003236Elevated circulating creatine kinase concentration
HP:0003394Muscle spasm
HP:0003781Excessive salivation
HP:0012378Fatigue
Периодический (5–29%)33
HP:0000020Urinary incontinence
HP:0000093Proteinuria
HP:0000713Agitation
HP:0000739Anxiety
HP:0001259Coma
HP:0001298Encephalopathy
HP:0001894Thrombocytosis
HP:0001919Acute kidney injury
HP:0001944Dehydration
HP:0002013Vomiting
HP:0002018Nausea
HP:0002072Chorea
HP:0002149Hyperuricemia
HP:0002153Hyperkalemia
HP:0002204Pulmonary embolism
HP:0002615Hypotension
HP:0002901Hypocalcemia
HP:0002902Hyponatremia
HP:0002905Hyperphosphatemia
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0002913Myoglobinuria
HP:0002917Hypomagnesemia
HP:0003155Elevated circulating alkaline phosphatase concentration
HP:0003201Rhabdomyolysis
HP:0003228Hypernatremia
HP:0010553Oculogyric crisis
HP:0011675Arrhythmia
HP:0011951Aspiration pneumonia
HP:0025145Rigors
HP:0025435Increased circulating lactate dehydrogenase concentration
HP:0031258Delirium
HP:0040288Nasogastric tube feeding
HP:0100735Hypertensive crisis
Очень редкий (1–4%)4
HP:0001662Bradycardia
HP:0001873Thrombocytopenia
HP:0002045Hypothermia
HP:0100806Sepsis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)