Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum
ORPHA:95455DiseaseNot applicableAll ages
Фенотипы (HPO)64
Очень частый (80–99%)5
HP:0001945Fever
HP:0008066Abnormal blistering of the skin
HP:0011123Inflammatory abnormality of the skin
HP:0012378Fatigue
HP:0030953Conjunctival hyperemia
Частый (30–79%)22
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003326Myalgia
HP:0012384Rhinitis
HP:0012735Cough
HP:0025426Abnormal bronchus morphology
HP:0025439Pharyngitis
HP:0031464Genital blistering
HP:0100792Acantholysis
HP:0200042Skin ulcer
HP:0200097Oral mucosal blisters
HP:0200136Oral-pharyngeal dysphagia
HP:0000509Conjunctivitis
HP:0000600Abnormality of the pharynx
HP:0000739Anxiety
HP:0000953Hyperpigmentation of the skin
HP:0000987Atypical scarring of skin
HP:0000988Skin rash
HP:0001097Keratoconjunctivitis sicca
HP:0001903Anemia
HP:0002039Anorexia
HP:0002098Respiratory distress
HP:0002315Headache
Периодический (5–29%)32
HP:0000036Abnormality of the penis
HP:0000217Xerostomia
HP:0000491Keratitis
HP:0000572Visual loss
HP:0000613Photophobia
HP:0000716Depression
HP:0000790Hematuria
HP:0001010Hypopigmentation of the skin
HP:0001128Trichiasis
HP:0001600Abnormality of the larynx
HP:0001875Decreased total neutrophil count
HP:0001919Acute kidney injury
HP:0002014Diarrhea
HP:0002090Pneumonia
HP:0003270Abdominal distention
HP:0004378Abnormality of the anus
HP:0004386Gastrointestinal inflammation
HP:0004887Respiratory failure requiring assisted ventilation
HP:0008404Nail dystrophy
HP:0008682Renal tubular epithelial necrosis
HP:0010285Oral synechia
HP:0011354Generalized abnormality of skin
HP:0012122Anterior uveitis
HP:0012375Chemosis
HP:0012594Microalbuminuria
HP:0025416Vaginal stricture
HP:0030943Vulvodynia
HP:0031088Vaginal dryness
HP:0031731Increased tear production
HP:0100518Dysuria
HP:0200020Corneal erosion
HP:0430007Symblepharon
Очень редкий (1–4%)5
HP:0000618Blindness
HP:0001798Anonychia
HP:0006528Chronic lung disease
HP:0031368Intestinal perforation
HP:0100806Sepsis
Эпидемиология5
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.19 | Worldwide | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | 1-9 / 1 000 000 | 0.8 | Taiwan, Province of China | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.189 | Germany | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.19 | United States | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)