Glucagonoma
ORPHA:97280DiseaseNot applicableAdult
Фенотипы (HPO)42
Очень частый (80–99%)1
HP:0002894Neoplasm of the pancreas
Частый (30–79%)18
HP:0000206Glossitis
HP:0000819Diabetes mellitus
HP:0000988Skin rash
HP:0000989Pruritus
HP:0001824Weight loss
HP:0001895Normochromic anemia
HP:0001927Acanthocytosis
HP:0002014Diarrhea
HP:0002017Nausea and vomiting
HP:0002019Constipation
HP:0002039Anorexia
HP:0002240Hepatomegaly
HP:0002574Episodic abdominal pain
HP:0004396Poor appetite
HP:0008066Abnormal blistering of the skin
HP:0010280Stomatitis
HP:0012432Chronic fatigue
HP:0031181Necrolytic migratory erythema
Периодический (5–29%)12
HP:0000716Depression
HP:0001046Intermittent jaundice
HP:0001406Intrahepatic cholestasis
HP:0001438Abnormality of abdomen morphology
HP:0001541Ascites
HP:0001907Thromboembolism
HP:0002239Gastrointestinal hemorrhage
HP:0002570Steatorrhea
HP:0005214Intestinal obstruction
HP:0012334Extrahepatic cholestasis
HP:0030145Lack of bowel sounds
HP:0030895Abnormal gastrointestinal motility
Очень редкий (1–4%)11
HP:0000820Abnormality of the thyroid gland
HP:0000837Increased circulating gonadotropin level
HP:0000845Elevated circulating growth hormone concentration
HP:0000870Increased circulating prolactin concentration
HP:0001031Subcutaneous lipoma
HP:0002893Pituitary adenoma
HP:0002897Parathyroid adenoma
HP:0003072Hypercalcemia
HP:0003118Increased circulating cortisol level
HP:0008200Primary hyperparathyroidism
HP:0008256Adrenocortical adenoma
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.005 | Europe | Value and class |
| Point prevalence | <1 / 1 000 000 | — | Europe | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)