Acquired von Willebrand syndrome
ORPHA:99147DiseaseNot applicableAdult
Фенотипы (HPO)27
Частый (30–79%)6
HP:0003125Reduced factor VIII activity
HP:0004377Hematological neoplasm
HP:0008151Prolonged prothrombin time
HP:0008330Reduced von Willebrand factor activity
HP:0030129Impaired ristocetin cofactor assay activity
HP:0030680Abnormal cardiovascular system morphology
Периодический (5–29%)20
HP:0000132Menorrhagia
HP:0000421Epistaxis
HP:0000471Gastrointestinal angiodysplasia
HP:0000790Hematuria
HP:0000978Bruising susceptibility
HP:0001642Pulmonic stenosis
HP:0001650Aortic valve stenosis
HP:0001653Mitral regurgitation
HP:0001659Aortic regurgitation
HP:0001897Normocytic anemia
HP:0001931Hypochromic anemia
HP:0001933Subcutaneous hemorrhage
HP:0001934Persistent bleeding after trauma
HP:0002239Gastrointestinal hemorrhage
HP:0002249Melena
HP:0002615Hypotension
HP:0005261Joint hemorrhage
HP:0005505Refractory anemia
HP:0025406Asthenia
HP:0100608Metrorrhagia
Очень редкий (1–4%)1
HP:0002170Intracranial hemorrhage
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Cases/families | — | 300 | Worldwide | Case(s) |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)