Marburg hemorrhagic fever
ORPHA:99826DiseaseAll ages
Фенотипы (HPO)74
Очень частый (80–99%)5
HP:0001882Leukopenia
HP:0001888Lymphopenia
HP:0010702Increased circulating antibody level
HP:0020071Viremia
HP:0030005Capillary leak
Частый (30–79%)16
HP:0001892Abnormal bleeding
HP:0001923Reticulocytosis
HP:0001945Fever
HP:0002013Vomiting
HP:0002014Diarrhea
HP:0002027Abdominal pain
HP:0002039Anorexia
HP:0002315Headache
HP:0003326Myalgia
HP:0004332Abnormal lymphocyte morphology
HP:0012137Abnormal number of granulocyte precursors
HP:0025143Chills
HP:0030953Conjunctival hyperemia
HP:0032043Odynophagia
HP:0032169Severe infection
HP:0410257Neutrophilia in presence of infection
Периодический (5–29%)40
HP:0002716Lymphadenopathy
HP:0002829Arthralgia
HP:0002900Hypokalemia
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003073Hypoalbuminemia
HP:0003128Lactic acidosis
HP:0003236Elevated circulating creatine kinase concentration
HP:0003256Abnormality of the coagulation cascade
HP:0003259Elevated circulating creatinine concentration
HP:0003418Back pain
HP:0003645Prolonged partial thromboplastin time
HP:0008151Prolonged prothrombin time
HP:0011029Internal hemorrhage
HP:0011151Obtundation status
HP:0011896Subconjunctival hemorrhage
HP:0012534Dysesthesia
HP:0025085Bloody diarrhea
HP:0030139Excessive bleeding after a venipuncture
HP:0031246Nonproductive cough
HP:0031273Shock
HP:0040186Maculopapular exanthema
HP:0410288Hyperamylasemia
HP:0000083Renal insufficiency
HP:0000718Aggressive behavior
HP:0000967Petechiae
HP:0000978Bruising susceptibility
HP:0000988Skin rash
HP:0001250Seizure
HP:0001254Lethargy
HP:0001259Coma
HP:0001289Confusion
HP:0001649Tachycardia
HP:0001662Bradycardia
HP:0001873Thrombocytopenia
HP:0001943Hypoglycemia
HP:0001944Dehydration
HP:0002018Nausea
HP:0002045Hypothermia
HP:0002329Drowsiness
HP:0002615Hypotension
Очень редкий (1–4%)13
HP:0000554Uveitis
HP:0000709Psychosis
HP:0000952Jaundice
HP:0001369Arthritis
HP:0001701Pericarditis
HP:0001733Pancreatitis
HP:0001987Hyperammonemia
HP:0002480Hepatic encephalopathy
HP:0004360Abnormality of acid-base homeostasis
HP:0005521Disseminated intravascular coagulation
HP:0011024Abnormality of the gastrointestinal tract
HP:0011106Hypovolemia
HP:0100796Orchitis
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Cases/families | — | 500 | Worldwide | Case(s) |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)