Cushing syndrome due to ectopic ACTH secretion
ORPHA:99889DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)83
Очень частый (80–99%)6
HP:0000819Diabetes mellitus
HP:0003118Increased circulating cortisol level
HP:0003154Increased circulating ACTH level
HP:0003466Paradoxical increased cortisol secretion on dexamethasone suppression test
HP:0012030Increased urinary cortisol level
HP:0030200Fatiguable weakness of proximal limb muscles
Частый (30–79%)34
HP:0000141Amenorrhea
HP:0000708Atypical behavior
HP:0000712Emotional lability
HP:0000739Anxiety
HP:0000822Hypertension
HP:0000939Osteoporosis
HP:0000953Hyperpigmentation of the skin
HP:0000963Thin skin
HP:0000978Bruising susceptibility
HP:0001007Hirsutism
HP:0001050Plethora
HP:0001058Poor wound healing
HP:0001061Acne
HP:0001065Striae distensae
HP:0001324Muscle weakness
HP:0001626Abnormality of the cardiovascular system
HP:0001888Lymphopenia
HP:0001956Truncal obesity
HP:0001974Leukocytosis
HP:0002721Immunodeficiency
HP:0004324Increased body weight
HP:0007126Proximal amyotrophy
HP:0008221Adrenal hyperplasia
HP:0010284Intra-oral hyperpigmentation
HP:0012743Abdominal obesity
HP:0025017Capillary fragility
HP:0025383Dorsocervical fat pad
HP:0025406Asthenia
HP:0030348Increased circulating androgen concentration
HP:0031364Ecchymosis
HP:0031845Abnormal libido
HP:0031891Decreased eosinophil count
HP:0100785Insomnia
HP:0500011Moon facies
Периодический (5–29%)26
HP:0000716Depression
HP:0000725Psychotic episodes
HP:0000869Secondary amenorrhea
HP:0000876Oligomenorrhea
HP:0000979Purpura
HP:0001297Stroke
HP:0001658Myocardial infarction
HP:0001824Weight loss
HP:0002014Diarrhea
HP:0002039Anorexia
HP:0002086Abnormality of the respiratory system
HP:0002209Sparse scalp hair
HP:0002354Memory impairment
HP:0002733Abnormality of the lymph nodes
HP:0002953Vertebral compression fracture
HP:0006749Malignant gastrointestinal tract tumors
HP:0011370Recurrent cutaneous fungal infections
HP:0012398Peripheral edema
HP:0030405Pancreatic endocrine tumor
HP:0030446Atypical pulmonary carcinoid tumor
HP:0031284Flushing
HP:0031589Suicidal ideation
HP:0040270Impaired glucose tolerance
HP:0100521Neoplasm of the thymus
HP:0100634Neuroendocrine neoplasm
HP:0200042Skin ulcer
Очень редкий (1–4%)15
HP:0000709Psychosis
HP:0000726Dementia
HP:0002666Pheochromocytoma
HP:0002865Medullary thyroid carcinoma
HP:0006722Small intestine carcinoid
HP:0006725Pancreatic adenocarcinoma
HP:0006753Neoplasm of the stomach
HP:0010741Pedal edema
HP:0011999Paranoia
HP:0012125Prostate cancer
HP:0025269Panic attack
HP:0030357Small cell lung carcinoma
HP:0030445Pulmonary carcinoid tumor
HP:0100757Pancreatoblastoma
HP:0500167Hypergastrinemia
Исключён (0%)2
HP:0002690Large sella turcica
HP:0008291Pituitary corticotropic cell adenoma
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)