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FRAXE intellectual disability

ORPHA:100973DiseaseX-linked recessiveAntenatal, Infancy, Neonatal

Ассоциированные гены (2)

AFF2
ALF transcription elongation factor 2
Disease-causing germline mutation(s) in
OMIM: 300806
FMR3
fragile X mental retardation associated 3
Disease-causing germline mutation(s) in

Фенотипы (21)

Частый (30–79%)18
HP:0000713Agitation
HP:0000718Aggressive behavior
HP:0000722Compulsive behaviors
HP:0000729Autistic behavior
HP:0000750Delayed speech and language development
HP:0000752Hyperactivity
HP:0001249Intellectual disability
HP:0001328Specific learning disability
HP:0001511Intrauterine growth retardation
HP:0001609Hoarse voice
HP:0002312Clumsiness
HP:0004322Short stature
HP:0009904Prominent ear helix
HP:0012471Thick vermilion border
HP:0100023Recurrent hand flapping
HP:0100710Impulsivity
HP:0000286Epicanthus
HP:0000426Prominent nasal bridge
Периодический (5–29%)3
HP:0000256Macrocephaly
HP:0004209Clinodactyly of the 5th finger
HP:0012172Stereotypical body rocking

Эпидемиология (1)

Point prevalence
1-9 / 1 000 000
Europe

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы