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Microphthalmia with brain and digit anomalies

ORPHA:139471Malformation syndromeAutosomal dominantAntenatal

Ассоциированные гены (1)

BMP4
bone morphogenetic protein 4
Disease-causing germline mutation(s) in
OMIM: 112262

Фенотипы (23)

Очень частый (80–99%)2
HP:0000528Anophthalmia
HP:0000568Microphthalmia
Частый (30–79%)5
HP:0000482Microcornea
HP:0000518Cataract
HP:0000567Chorioretinal coloboma
HP:0000612Iris coloboma
HP:0001263Global developmental delay
Периодический (5–29%)16
HP:0000028Cryptorchidism
HP:0000218High palate
HP:0000252Microcephaly
HP:0000407Sensorineural hearing impairment
HP:0000545Myopia
HP:0000556Retinal dystrophy
HP:0000639Nystagmus
HP:0000647Sclerocornea
HP:0000864Abnormality of the hypothalamus-pituitary axis
HP:0001250Seizure
HP:0001274Agenesis of corpus callosum
HP:0001830Postaxial foot polydactyly
HP:0002164Nail dysplasia
HP:0006101Finger syndactyly
HP:0007068Inferior vermis hypoplasia
HP:0009623Proximal placement of thumb

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы