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Familial calcium pyrophosphate deposition

ORPHA:1416DiseaseAutosomal dominant, Not applicableAdult

Ассоциированные гены (2)

TNFRSF11B
TNF receptor superfamily member 11b
Candidate gene tested in
OMIM: 602643
ANKH
ANKH inorganic pyrophosphate transport regulator
Disease-causing germline mutation(s) in
OMIM: 605145

Фенотипы (17)

Очень частый (80–99%)5
HP:0001369Arthritis
HP:0001386Joint swelling
HP:0002829Arthralgia
HP:0005108Abnormal intervertebral disk morphology
HP:0100593Calcification of cartilage
Частый (30–79%)1
HP:0002758Osteoarthritis
Периодический (5–29%)10
HP:0000934Chondrocalcinosis
HP:0001373Joint dislocation
HP:0001376Limitation of joint mobility
HP:0001387Joint stiffness
HP:0001945Fever
HP:0004349Reduced bone mineral density
HP:0012649Increased inflammatory response
HP:0031013Ankylosis
HP:0045082Decreased body mass index
HP:0100769Synovitis
Очень редкий (1–4%)1
HP:0001250Seizure

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы