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Jackson-Weiss syndrome

ORPHA:1540Malformation syndromeAutosomal dominantNeonatal

Ассоциированные гены (1)

FGFR2
fibroblast growth factor receptor 2
Disease-causing germline mutation(s) in
OMIM: 176943

Фенотипы (21)

Очень частый (80–99%)7
HP:0000262Turricephaly
HP:0000316Hypertelorism
HP:0001770Toe syndactyly
HP:0001783Broad metatarsal
HP:0010059Broad hallux phalanx
HP:0010743Short metatarsal
HP:0011800Midface retrusion
Частый (30–79%)9
HP:0000174Abnormal palate morphology
HP:0000303Mandibular prognathia
HP:0000327Hypoplasia of the maxilla
HP:0000444Convex nasal ridge
HP:0000486Strabismus
HP:0000508Ptosis
HP:0000520Proptosis
HP:0002007Frontal bossing
HP:0009891Underdeveloped supraorbital ridges
Периодический (5–29%)5
HP:0001839Split foot
HP:0001841Preaxial foot polydactyly
HP:0002991Abnormal fibula morphology
HP:00046912-3 toe syndactyly
HP:0009773Symphalangism affecting the phalanges of the hand

Эпидемиология (2)

Point prevalence
<1 / 1 000 000
Worldwide
Cases/families
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы