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Crisponi syndrome

ORPHA:1545Malformation syndromeAutosomal recessiveNeonatal

Ассоциированные гены (2)

CRLF1
cytokine receptor like factor 1
Disease-causing germline mutation(s) in
OMIM: 604237
CLCF1
cardiotrophin like cytokine factor 1
Disease-causing germline mutation(s) in
OMIM: 607672

Фенотипы (23)

Очень частый (80–99%)17
HP:0000293Full cheeks
HP:0000343Long philtrum
HP:0000445Wide nose
HP:0000463Anteverted nares
HP:0000966Hypohidrosis
HP:0000975Hyperhidrosis
HP:0001276Hypertonia
HP:0001371Flexion contracture
HP:0001522Death in infancy
HP:0001645Sudden cardiac death
HP:0002047Malignant hyperthermia
HP:0002093Respiratory insufficiency
HP:0002650Scoliosis
HP:0002808Kyphosis
HP:0011968Feeding difficulties
HP:0100490Camptodactyly of finger
HP:0100729Large face
Частый (30–79%)3
HP:0000218High palate
HP:0001376Limitation of joint mobility
HP:0100543Cognitive impairment
Периодический (5–29%)3
HP:0000160Narrow mouth
HP:0000347Micrognathia
HP:0001250Seizure

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы