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Curry-Jones syndrome

ORPHA:1553Malformation syndromeNot applicableNeonatal

Ассоциированные гены (1)

SMO
smoothened, frizzled class receptor
Disease-causing somatic mutation(s) in
OMIM: 601500

Фенотипы (19)

Очень частый (80–99%)3
HP:0000316Hypertelorism
HP:0001053Hypopigmented skin patches
HP:0006101Finger syndactyly
Частый (30–79%)12
HP:0000324Facial asymmetry
HP:0000568Microphthalmia
HP:0001249Intellectual disability
HP:0001274Agenesis of corpus callosum
HP:0001363Craniosynostosis
HP:0001770Toe syndactyly
HP:0001829Foot polydactyly
HP:0002119Ventriculomegaly
HP:0002230Generalized hirsutism
HP:0008065Aplasia/Hypoplasia of the skin
HP:0009602Abnormality of thumb phalanx
HP:0011304Broad thumb
Периодический (5–29%)4
HP:0000588Optic disc coloboma
HP:0000612Iris coloboma
HP:0001177Preaxial hand polydactyly
HP:0002566Intestinal malrotation

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы