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Mesoaxial synostotic syndactyly with phalangeal reduction

ORPHA:157801Morphological anomalyAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

BHLHA9
basic helix-loop-helix family member a9
Disease-causing germline mutation(s) in
OMIM: 615416

Фенотипы (12)

Очень частый (80–99%)11
HP:0001770Toe syndactyly
HP:0004209Clinodactyly of the 5th finger
HP:0004279Short palm
HP:00046912-3 toe syndactyly
HP:0006101Finger syndactyly
HP:0008362Aplasia/Hypoplasia of the hallux
HP:0009701Metacarpal synostosis
HP:0009773Symphalangism affecting the phalanges of the hand
HP:0009778Short thumb
HP:0009843Aplasia/Hypoplasia of the middle phalanges of the hand
HP:0010109Short hallux
Частый (30–79%)1
HP:0005048Synostosis of carpal bones

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы