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Sudden infant death-dysgenesis of the testes syndrome

ORPHA:168593Malformation syndromeAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

TSPYL1
TSPY like 1
Disease-causing germline mutation(s) (loss of function) in
OMIM: 604714

Фенотипы (17)

Очень частый (80–99%)12
HP:0000028Cryptorchidism
HP:0000046Small scrotum
HP:0000062Ambiguous genitalia
HP:0001522Death in infancy
HP:0001695Cardiac arrest
HP:0002020Gastroesophageal reflux
HP:0002045Hypothermia
HP:0002793Abnormal pattern of respiration
HP:0008736Hypoplasia of penis
HP:0010535Sleep apnea
HP:0011675Arrhythmia
HP:0012332Abnormal autonomic nervous system physiology
Частый (30–79%)5
HP:0000602Ophthalmoplegia
HP:0001265Hyporeflexia
HP:0001336Myoclonus
HP:0001510Growth delay
HP:0001608Abnormality of the voice

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы