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Cernunnos-XLF deficiency

ORPHA:169079DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

NHEJ1
non-homologous end joining factor 1
Disease-causing germline mutation(s) in
OMIM: 611290

Фенотипы (16)

Очень частый (80–99%)10
HP:0000252Microcephaly
HP:0000320Bird-like facies
HP:0000340Sloping forehead
HP:0000414Bulbous nose
HP:0000444Convex nasal ridge
HP:0001510Growth delay
HP:0001888Lymphopenia
HP:0004313Decreased circulating antibody level
HP:0005403Decreased total T cell count
HP:0010976Decreased total B cell count
Частый (30–79%)2
HP:0001873Thrombocytopenia
HP:0001903Anemia
Периодический (5–29%)4
HP:0002718Recurrent bacterial infections
HP:0002721Immunodeficiency
HP:0002960Autoimmunity
HP:0004429Recurrent viral infections

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы