Moderate hemophilia A
ORPHA:169805Clinical subtypeX-linked recessiveInfancy, Neonatal
Ассоциированные гены1
Фенотипы (HPO)26
Очень частый (80–99%)3
HP:0001892Abnormal bleeding
HP:0003125Reduced factor VIII activity
HP:0003645Prolonged partial thromboplastin time
Частый (30–79%)6
HP:0000225Gingival bleeding
HP:0001933Subcutaneous hemorrhage
HP:0002829Arthralgia
HP:0005261Joint hemorrhage
HP:0011889Bleeding with minor or no trauma
HP:0012233Intramuscular hematoma
Периодический (5–29%)12
HP:0000790Hematuria
HP:0001376Limitation of joint mobility
HP:0001386Joint swelling
HP:0002170Intracranial hemorrhage
HP:0002239Gastrointestinal hemorrhage
HP:0002315Headache
HP:0003040Arthropathy
HP:0004846Prolonged bleeding after surgery
HP:0006298Prolonged bleeding after dental extraction
HP:0100309Subdural hemorrhage
HP:0100769Synovitis
HP:0100773Cartilage destruction
Очень редкий (1–4%)5
HP:0030746Intraventricular hemorrhage
HP:0100310Epidural hemorrhage
HP:0001250Seizure
HP:0003273Hip contracture
HP:0007420Spontaneous hematomas
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)