← Назад

Spondyloepimetaphyseal dysplasia, aggrecan type

ORPHA:171866DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

ACAN
aggrecan
Disease-causing germline mutation(s) in
OMIM: 155760

Фенотипы (16)

Очень частый (80–99%)14
HP:0000303Mandibular prognathia
HP:0000358Posteriorly rotated ears
HP:0000470Short neck
HP:0001156Brachydactyly
HP:0001382Joint hypermobility
HP:0001552Barrel-shaped chest
HP:0001597Abnormality of the nail
HP:0002938Lumbar hyperlordosis
HP:0003027Mesomelia
HP:0004482Relative macrocephaly
HP:0005285Absent nasal bridge
HP:0008905Rhizomelia
HP:0011304Broad thumb
HP:0011800Midface retrusion
Частый (30–79%)2
HP:0001609Hoarse voice
HP:0002795Abnormal respiratory system physiology

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы