Herpes simplex virus encephalitis
ORPHA:1930DiseaseMultigenic/multifactorial, Not applicableAll ages
Ассоциированные гены5
| Ген | Полное название | Тип связи | Тип гена | OMIM |
|---|---|---|---|---|
| UNC93B1 | unc-93B1 regulator of TLR signaling | Major susceptibility factor in | gene with protein product | 608204 |
| TLR3 | toll like receptor 3 | Major susceptibility factor in | gene with protein product | 603029 |
| TICAM1 | TIR domain containing adaptor molecule 1 | Major susceptibility factor in | gene with protein product | 607601 |
| TRAF3 | TNF receptor associated factor 3 | Major susceptibility factor in | gene with protein product | 601896 |
| TBK1 | TANK binding kinase 1 | Major susceptibility factor in | gene with protein product | 604834 |
Фенотипы (HPO)30
Очень частый (80–99%)4
HP:0002353EEG abnormality
HP:0004372Reduced consciousness/confusion
HP:0012443Abnormality of brain morphology
HP:0200149CSF lymphocytic pleiocytosis
Частый (30–79%)13
HP:0001250Seizure
HP:0001945Fever
HP:0001974Leukocytosis
HP:0002017Nausea and vomiting
HP:0002167Abnormality of speech or vocalization
HP:0002315Headache
HP:0002902Hyponatremia
HP:0002922Increased CSF protein concentration
HP:0004887Respiratory failure requiring assisted ventilation
HP:0007185Loss of consciousness
HP:0011897Neutrophilia
HP:0012378Fatigue
HP:0031179Nuchal rigidity
Периодический (5–29%)13
HP:0001259Coma
HP:0001262Excessive daytime somnolence
HP:0001347Hyperreflexia
HP:0002133Status epilepticus
HP:0002181Cerebral edema
HP:0002349Focal aware seizure
HP:0002384Focal impaired awareness seizure
HP:0002721Immunodeficiency
HP:0004302Functional motor deficit
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011972Hypoglycorrhachia
HP:0025143Chills
HP:0030955Alcoholism
Эпидемиология4
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Worldwide | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | United Kingdom | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | United States | Value and class |
| Point prevalence | Unknown | — | Europe | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)