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Pulmonary capillary hemangiomatosis

ORPHA:199241DiseaseAutosomal dominant, Autosomal recessive, Not applicableAll ages

Ассоциированные гены (1)

EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
Disease-causing germline mutation(s) (loss of function) in
OMIM: 609280

Фенотипы (25)

Очень частый (80–99%)6
HP:0002716Lymphadenopathy
HP:0005954Pulmonary capillary hemangiomatosis
HP:0025104Capillary malformation
HP:0025179Ground-glass opacification on pulmonary HRCT
HP:0030879Interlobular septal thickening on pulmonary HRCT
HP:0045051Decreased DLCO
Частый (30–79%)14
HP:0000961Cyanosis
HP:0001708Right ventricular failure
HP:0002094Dyspnea
HP:0002105Hemoptysis
HP:0002875Exertional dyspnea
HP:0004890Elevated pulmonary artery pressure
HP:0010741Pedal edema
HP:0012151Hemothorax
HP:0012418Hypoxemia
HP:0025180Centrilobular ground-glass opacification on pulmonary HRCT
HP:0025420Diffuse alveolar hemorrhage
HP:0030968Abnormal pulmonary vein morphology
HP:0100721Mediastinal lymphadenopathy
HP:0100759Clubbing of fingers
Периодический (5–29%)2
HP:0002202Pleural effusion
HP:0100598Pulmonary edema
Очень редкий (1–4%)1
HP:0001698Pericardial effusion
Исключён (0%)2
HP:0003493Antinuclear antibody positivity
HP:0032230Cytoplasmic antineutrophil antibody positivity

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы