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Symptomatic form of muscular dystrophy of Duchenne and Becker in female carriers

ORPHA:206546DiseaseX-linked recessiveAdult

Ассоциированные гены (1)

DMD
dystrophin
Disease-causing germline mutation(s) in
OMIM: 300377

Фенотипы (20)

Частый (30–79%)3
HP:0002938Lumbar hyperlordosis
HP:0003236Elevated circulating creatine kinase concentration
HP:0003701Proximal muscle weakness
Периодический (5–29%)13
HP:0001435Abnormality of the shoulder girdle musculature
HP:0001644Dilated cardiomyopathy
HP:0001712Left ventricular hypertrophy
HP:0002540Inability to walk
HP:0002942Thoracic kyphosis
HP:0002943Thoracic scoliosis
HP:0003324Generalized muscle weakness
HP:0003326Myalgia
HP:0003394Muscle spasm
HP:0003710Exercise-induced muscle cramps
HP:0003731Quadriceps muscle weakness
HP:0008981Calf muscle hypertrophy
HP:0030097Absent muscle dystrophin expression
Очень редкий (1–4%)2
HP:0001635Congestive heart failure
HP:0002987Elbow flexion contracture
Исключён (0%)2
HP:0002380Fasciculations
HP:0003409Distal sensory impairment of all modalities

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы