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Adult polyglucosan body disease

ORPHA:206583Clinical subtypeAutosomal recessiveAdult

Ассоциированные гены (1)

GBE1
1,4-alpha-glucan branching enzyme 1
Disease-causing germline mutation(s) in
OMIM: 607839

Фенотипы (18)

Очень частый (80–99%)10
HP:0000011Neurogenic bladder
HP:0000020Urinary incontinence
HP:0001249Intellectual disability
HP:0001257Spasticity
HP:0001269Hemiparesis
HP:0001288Gait disturbance
HP:0001324Muscle weakness
HP:0002839Urinary bladder sphincter dysfunction
HP:0007256Abnormal pyramidal sign
HP:0009830Peripheral neuropathy
Частый (30–79%)3
HP:0000708Atypical behavior
HP:0002936Distal sensory impairment
HP:0200042Skin ulcer
Периодический (5–29%)5
HP:0000726Dementia
HP:0001251Ataxia
HP:0001376Limitation of joint mobility
HP:0002071Abnormality of extrapyramidal motor function
HP:0003457EMG abnormality

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы