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17p13.3 microduplication syndrome

ORPHA:217385Malformation syndromeNot applicable, UnknownInfancy, Neonatal

Ассоциированные гены (2)

PAFAH1B1
platelet activating factor acetylhydrolase 1b regulatory subunit 1
Role in the phenotype of
OMIM: 601545
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Role in the phenotype of
OMIM: 605066

Фенотипы (19)

Очень частый (80–99%)8
HP:0000160Narrow mouth
HP:0000316Hypertelorism
HP:0000348High forehead
HP:0000445Wide nose
HP:0001252Hypotonia
HP:0001263Global developmental delay
HP:0002007Frontal bossing
HP:0003196Short nose
Частый (30–79%)3
HP:0000369Low-set ears
HP:0000470Short neck
HP:0000494Downslanted palpebral fissures
Периодический (5–29%)8
HP:0000023Inguinal hernia
HP:0000098Tall stature
HP:0000218High palate
HP:0001374Congenital hip dislocation
HP:0002079Hypoplasia of the corpus callosum
HP:0002119Ventriculomegaly
HP:0004209Clinodactyly of the 5th finger
HP:0008736Hypoplasia of penis

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы