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Silver-Russell syndrome due to 11p15 microduplication

ORPHA:231144Etiological subtypeAutosomal dominant, Not applicableAntenatal, Neonatal

Ассоциированные гены (2)

H19
H19 imprinted maternally expressed transcript
Role in the phenotype of
OMIM: 103280
IGF2
insulin like growth factor 2
Role in the phenotype of
OMIM: 147470

Фенотипы (19)

Частый (30–79%)9
HP:0000325Triangular face
HP:0001508Failure to thrive
HP:0001511Intrauterine growth retardation
HP:0001518Small for gestational age
HP:0001562Oligohydramnios
HP:0002750Delayed skeletal maturation
HP:0004209Clinodactyly of the 5th finger
HP:0004322Short stature
HP:0008897Postnatal growth retardation
Периодический (5–29%)10
HP:0000324Facial asymmetry
HP:0001270Motor delay
HP:0001328Specific learning disability
HP:0001537Umbilical hernia
HP:0001558Decreased fetal movement
HP:0004482Relative macrocephaly
HP:0008846Severe intrauterine growth retardation
HP:0008947Floppy infant
HP:0011220Prominent forehead
HP:0011800Midface retrusion

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы