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Juberg-Hayward syndrome

ORPHA:2319Malformation syndromeAutosomal dominant, Autosomal recessiveAntenatal, Neonatal

Ассоциированные гены (1)

ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
Disease-causing germline mutation(s) in
OMIM: 609353

Фенотипы (26)

Очень частый (80–99%)4
HP:0000252Microcephaly
HP:0000445Wide nose
HP:0001511Intrauterine growth retardation
HP:0003510Severe short stature
Частый (30–79%)19
HP:0000047Hypospadias
HP:0000085Horseshoe kidney
HP:0000202Orofacial cleft
HP:0000316Hypertelorism
HP:0000534Abnormal eyebrow morphology
HP:0000772Abnormal rib morphology
HP:0001167Abnormality of finger
HP:0001249Intellectual disability
HP:0001765Hammertoe
HP:0001770Toe syndactyly
HP:0002553Highly arched eyebrow
HP:0002650Scoliosis
HP:0002974Radioulnar synostosis
HP:0002984Hypoplasia of the radius
HP:0003019Abnormality of the wrist
HP:0003468Abnormal vertebral morphology
HP:0005916Abnormal metacarpal morphology
HP:0009778Short thumb
HP:0009811Abnormality of the elbow
Периодический (5–29%)3
HP:0000508Ptosis
HP:0001305Dandy-Walker malformation
HP:0001545Anteriorly placed anus

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы