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Progressive supranuclear palsy-predominant parkinsonism syndrome

ORPHA:240085Clinical subtypeNot applicableAdult

Ассоциированные гены (1)

MAPT
microtubule associated protein tau
Major susceptibility factor in
OMIM: 157140

Фенотипы (20)

Очень частый (80–99%)4
HP:0002172Postural instability
HP:0002548Parkinsonism with favorable response to dopaminergic medication
HP:0000511Vertical supranuclear gaze palsy
HP:0000570Abnormal saccadic eye movements
Частый (30–79%)10
HP:0002067Bradykinesia
HP:0006921Axial muscle stiffness
HP:0002063Rigidity
HP:0001337Tremor
HP:0000496Abnormality of eye movement
HP:0001268Mental deterioration
HP:0002527Falls
HP:0001332Dystonia
HP:0000716Depression
HP:0002167Abnormality of speech or vocalization
Периодический (5–29%)5
HP:0002098Respiratory distress
HP:0002068Neuromuscular dysphagia
HP:0000741Apathy
HP:0010794Impaired visuospatial constructive cognition
HP:0002354Memory impairment
Исключён (0%)1
HP:0000739Anxiety

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы