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Acrogeria

ORPHA:2500Malformation syndromeUnknownChildhood, Infancy

Ассоциированные гены (1)

COL3A1
collagen type III alpha 1 chain
Disease-causing germline mutation(s) in
OMIM: 120180

Фенотипы (19)

Очень частый (80–99%)9
HP:0001382Joint hypermobility
HP:0000951Abnormality of the skin
HP:0000963Thin skin
HP:0002213Fine hair
HP:0004322Short stature
HP:0007400Irregular hyperpigmentation
HP:0007495Prematurely aged appearance
HP:0008065Aplasia/Hypoplasia of the skin
HP:0100578Lipoatrophy
Частый (30–79%)8
HP:0000347Micrognathia
HP:0000444Convex nasal ridge
HP:0001249Intellectual disability
HP:0001773Short foot
HP:0002650Scoliosis
HP:0007392Excessive wrinkled skin
HP:0100585Telangiectasia of the skin
HP:0200055Small hand
Периодический (5–29%)2
HP:0002652Skeletal dysplasia
HP:0200042Skin ulcer

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы