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Familial hyperaldosteronism type III

ORPHA:251274DiseaseAutosomal dominantAdolescent, Childhood, Infancy

Ассоциированные гены (1)

KCNJ5
potassium inwardly rectifying channel subfamily J member 5
Disease-causing germline mutation(s) (gain of function) in
OMIM: 600734

Фенотипы (17)

Облигатный (100%)2
HP:0000822Hypertension
HP:0040084Abnormal circulating renin
Очень частый (80–99%)3
HP:0002900Hypokalemia
HP:0008221Adrenal hyperplasia
HP:0011740Glucocortocoid-insensitive primary hyperaldosteronism
Периодический (5–29%)11
HP:0000360Tinnitus
HP:0000421Epistaxis
HP:0001324Muscle weakness
HP:0001657Prolonged QT interval
HP:0001712Left ventricular hypertrophy
HP:0001959Polydipsia
HP:0002018Nausea
HP:0002150Hypercalciuria
HP:0002170Intracranial hemorrhage
HP:0002315Headache
HP:0200114Metabolic alkalosis
Исключён (0%)1
HP:0011739Dexamethasone-suppresible primary hyperaldosteronism

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы