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20p12.3 microdeletion syndrome

ORPHA:261295Malformation syndromeNot applicable, UnknownInfancy, Neonatal

Ассоциированные гены (1)

BMP2
bone morphogenetic protein 2
Role in the phenotype of
OMIM: 112261

Фенотипы (23)

Очень частый (80–99%)2
HP:0000316Hypertelorism
HP:0001263Global developmental delay
Частый (30–79%)8
HP:0000160Narrow mouth
HP:0000256Macrocephaly
HP:0000272Malar flattening
HP:0000286Epicanthus
HP:0000327Hypoplasia of the maxilla
HP:0000494Downslanted palpebral fissures
HP:0001716Wolff-Parkinson-White syndrome
HP:0004322Short stature
Периодический (5–29%)13
HP:0000293Full cheeks
HP:0000343Long philtrum
HP:0000391Thickened helices
HP:0000431Wide nasal bridge
HP:0000768Pectus carinatum
HP:0001250Seizure
HP:0001252Hypotonia
HP:0001631Atrial septal defect
HP:0002119Ventriculomegaly
HP:0005280Depressed nasal bridge
HP:0008551Microtia
HP:0010059Broad hallux phalanx
HP:0011304Broad thumb

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы