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Xq27.3q28 duplication syndrome

ORPHA:261483Malformation syndromeX-linked recessiveInfancy, Neonatal

Ассоциированные гены (1)

FMR1
fragile X messenger ribonucleoprotein 1
Role in the phenotype of
OMIM: 309550

Фенотипы (19)

Очень частый (80–99%)13
HP:0000028Cryptorchidism
HP:0000135Hypogonadism
HP:0000233Thin vermilion border
HP:0000414Bulbous nose
HP:0000490Deeply set eye
HP:0001256Intellectual disability, mild
HP:0001263Global developmental delay
HP:0001508Failure to thrive
HP:0001620Abnormally high-pitched voice
HP:0001773Short foot
HP:0004322Short stature
HP:0008734Decreased testicular size
HP:0200055Small hand
Частый (30–79%)6
HP:0000771Gynecomastia
HP:0001252Hypotonia
HP:0001511Intrauterine growth retardation
HP:0001956Truncal obesity
HP:0002231Sparse body hair
HP:0002750Delayed skeletal maturation

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы