← Назад

Piebaldism

ORPHA:2884DiseaseAutosomal dominantInfancy, Neonatal

Ассоциированные гены (2)

SNAI2
snail family transcriptional repressor 2
Disease-causing germline mutation(s) in
OMIM: 602150
KIT
KIT proto-oncogene, receptor tyrosine kinase
Disease-causing germline mutation(s) (loss of function) in
OMIM: 164920

Фенотипы (19)

Очень частый (80–99%)3
HP:0002211White forelock
HP:0005599Hypopigmentation of hair
HP:0007544Piebaldism
Частый (30–79%)4
HP:0001053Hypopigmented skin patches
HP:0002226White eyebrow
HP:0002227White eyelashes
HP:0012733Macule
Периодический (5–29%)12
HP:0000252Microcephaly
HP:0000343Long philtrum
HP:0000365Hearing impairment
HP:0000431Wide nasal bridge
HP:0000664Synophrys
HP:0001100Heterochromia iridis
HP:0001249Intellectual disability
HP:0001251Ataxia
HP:0001252Hypotonia
HP:0002251Aganglionic megacolon
HP:0002683Abnormality of the calvaria
HP:0008069Neoplasm of the skin

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы