Multiple myeloma
ORPHA:29073DiseaseNot applicableAdult
Ассоциированные гены1
Фенотипы (HPO)31
Очень частый (80–99%)2
HP:0000938Osteopenia
HP:0002756Pathologic fracture
Частый (30–79%)13
HP:0000100Nephrotic syndrome
HP:0000112Nephropathy
HP:0000980Pallor
HP:0001903Anemia
HP:0001919Acute kidney injury
HP:0002152Hyperproteinemia
HP:0002653Bone pain
HP:0002797Osteolysis
HP:0003237Increased circulating IgG level
HP:0003259Elevated circulating creatinine concentration
HP:0003324Generalized muscle weakness
HP:0004313Decreased circulating antibody level
HP:0012378Fatigue
Периодический (5–29%)13
HP:0000014Abnormality of the bladder
HP:0000098Tall stature
HP:0001824Weight loss
HP:0002176Spinal cord compression
HP:0002808Kyphosis
HP:0002953Vertebral compression fracture
HP:0003072Hypercalcemia
HP:0003261Increased circulating IgA level
HP:0003401Paresthesia
HP:0004341Abnormality of vitamin B12 metabolism
HP:0009830Peripheral neuropathy
HP:0012185Constrictive median neuropathy
HP:0012719Functional abnormality of the gastrointestinal tract
Очень редкий (1–4%)3
HP:0001744Splenomegaly
HP:0002202Pleural effusion
HP:0002716Lymphadenopathy
Эпидемиология9
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Prevalence at birth | 1-9 / 100 000 | 3.8 | United States | Value and class |
| Annual incidence | 1-9 / 100 000 | 6 | Worldwide | Value and class |
| Point prevalence | 1-5 / 10 000 | 11.9 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 7.7 | France | Value and class |
| Annual incidence | 1-9 / 100 000 | 2.4 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 5.6 | United States | Value and class |
| Annual incidence | 1-9 / 100 000 | 2 | Iran, Islamic Republic of | Value and class |
| Annual incidence | 1-9 / 100 000 | 5.1 | Australia | Value and class |
| Annual incidence | 1-9 / 100 000 | 6.2 | Denmark | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)