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Orofaciodigital syndrome type 5

ORPHA:2919Malformation syndromeAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

DDX59
DEAD-box helicase 59
Disease-causing germline mutation(s) in
OMIM: 615464

Фенотипы (27)

Очень частый (80–99%)3
HP:0000161Median cleft lip
HP:0001162Postaxial hand polydactyly
HP:0001830Postaxial foot polydactyly
Частый (30–79%)6
HP:0000191Accessory oral frenulum
HP:0000288Abnormality of the philtrum
HP:0000316Hypertelorism
HP:0001249Intellectual disability
HP:0002007Frontal bossing
HP:0010297Bifid tongue
Периодический (5–29%)18
HP:0002251Aganglionic megacolon
HP:0002650Scoliosis
HP:0002705High, narrow palate
HP:0004736Crossed fused renal ectopia
HP:0005817Postaxial polysyndactyly of foot
HP:0006297Enamel hypoplasia
HP:0010441Ectopic accessory finger-like appendage
HP:0010800Absent cupid's bow
HP:0011069Supernumerary tooth
HP:0012738Agenesis of canine
HP:0100335Non-midline cleft of the upper lip
HP:0000185Cleft soft palate
HP:0000190Abnormal oral frenulum morphology
HP:0000193Bifid uvula
HP:0000252Microcephaly
HP:0000668Hypodontia
HP:0001274Agenesis of corpus callosum
HP:0001636Tetralogy of Fallot

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы