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Proximal symphalangism

ORPHA:3250Malformation syndromeAutosomal dominantInfancy, Neonatal

Ассоциированные гены (2)

GDF5
growth differentiation factor 5
Disease-causing germline mutation(s) (gain of function) in
OMIM: 601146
NOG
noggin
Disease-causing germline mutation(s) in
OMIM: 602991

Фенотипы (15)

Очень частый (80–99%)4
HP:0005048Synostosis of carpal bones
HP:0008368Tarsal synostosis
HP:0100264Proximal symphalangism
HP:0100490Camptodactyly of finger
Частый (30–79%)7
HP:0000407Sensorineural hearing impairment
HP:0001156Brachydactyly
HP:0003042Elbow dislocation
HP:0003070Elbow ankylosis
HP:0005880Metacarpophalangeal synostosis
HP:0005916Abnormal metacarpal morphology
HP:0040019Finger clinodactyly
Периодический (5–29%)4
HP:0000486Strabismus
HP:0003019Abnormality of the wrist
HP:0004209Clinodactyly of the 5th finger
HP:0006101Finger syndactyly

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы