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Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome

ORPHA:330054DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

GFER
growth factor, augmenter of liver regeneration
Disease-causing germline mutation(s) in
OMIM: 600924

Фенотипы (13)

Частый (30–79%)12
HP:0000408Progressive sensorineural hearing impairment
HP:0000508Ptosis
HP:0000519Developmental cataract
HP:0001252Hypotonia
HP:0001263Global developmental delay
HP:0001315Reduced tendon reflexes
HP:0001583Rotary nystagmus
HP:0002079Hypoplasia of the corpus callosum
HP:0003128Lactic acidosis
HP:0008936Axial hypotonia
HP:0012343Decreased serum ferritin
HP:0030089Abnormal muscle fiber protein expression
Исключён (0%)1
HP:0001324Muscle weakness

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы