← Назад

Congenital amegakaryocytic thrombocytopenia

ORPHA:3319DiseaseAutosomal recessiveNeonatal

Ассоциированные гены (2)

THPO
thrombopoietin
Disease-causing germline mutation(s) in
OMIM: 600044
MPL
MPL proto-oncogene, thrombopoietin receptor
Disease-causing germline mutation(s) (loss of function) in
OMIM: 159530

Фенотипы (11)

Очень частый (80–99%)2
HP:0001873Thrombocytopenia
HP:0011902Abnormal hemoglobin
Частый (30–79%)7
HP:0000280Coarse facial features
HP:0000470Short neck
HP:0000995Melanocytic nevus
HP:0001903Anemia
HP:0002650Scoliosis
HP:0003312Abnormal form of the vertebral bodies
HP:0004322Short stature
Периодический (5–29%)2
HP:0001671Abnormal cardiac septum morphology
HP:0004331Decreased skull ossification

Эпидемиология (3)

Point prevalence
Unknown
Worldwide
Cases/families
Worldwide
Prevalence at birth
1-9 / 1 000 000
United Kingdom

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы