Waldenström macroglobulinemia
ORPHA:33226DiseaseMultigenic/multifactorialElderly
Ассоциированные гены1
Фенотипы (HPO)45
Очень частый (80–99%)3
HP:0001909Leukemia
HP:0002665Lymphoma
HP:0005508Monoclonal immunoglobulin M proteinemia
Частый (30–79%)7
HP:0000225Gingival bleeding
HP:0000980Pallor
HP:0001874Abnormality of neutrophils
HP:0001897Normocytic anemia
HP:0002093Respiratory insufficiency
HP:0002321Vertigo
HP:0100724Hypercoagulability
Периодический (5–29%)35
HP:0000083Renal insufficiency
HP:0000365Hearing impairment
HP:0000421Epistaxis
HP:0000520Proptosis
HP:0000573Retinal hemorrhage
HP:0000965Cutis marmorata
HP:0000979Purpura
HP:0001025Urticaria
HP:0001251Ataxia
HP:0001297Stroke
HP:0001635Congestive heart failure
HP:0001744Splenomegaly
HP:0001945Fever
HP:0002014Diarrhea
HP:0002024Malabsorption
HP:0002039Anorexia
HP:0002076Migraine
HP:0002113Pulmonary infiltrates
HP:0002202Pleural effusion
HP:0002239Gastrointestinal hemorrhage
HP:0002240Hepatomegaly
HP:0002354Memory impairment
HP:0002633Vasculitis
HP:0002716Lymphadenopathy
HP:0002719Recurrent infections
HP:0003565Elevated erythrocyte sedimentation rate
HP:0004372Reduced consciousness/confusion
HP:0006824Cranial nerve paralysis
HP:0008046Abnormal retinal vascular morphology
HP:0009830Peripheral neuropathy
HP:0010741Pedal edema
HP:0010841Multifocal epileptiform discharges
HP:0012378Fatigue
HP:0100539Periorbital edema
HP:0100778Cryoglobulinemia
Эпидемиология7
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.81 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 2.05 | France | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.38 | United States | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.55 | United Kingdom | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.31 | Spain | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
| Point prevalence | 1-9 / 100 000 | — | Europe | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)