Kleine-Levin syndrome
ORPHA:33543DiseaseAdolescent, Adult, Childhood
Ассоциированные гены1
Фенотипы (HPO)35
Очень частый (80–99%)3
HP:0001289Confusion
HP:0007200Episodic hypersomnia
HP:0100543Cognitive impairment
Частый (30–79%)19
HP:5200321Amplification of sexual behavior
HP:0000613Photophobia
HP:0000713Agitation
HP:0000716Depression
HP:0000737Irritability
HP:0000739Anxiety
HP:0000741Apathy
HP:0000975Hyperhidrosis
HP:0001945Fever
HP:0002167Abnormality of speech or vocalization
HP:0002315Headache
HP:0002591Polyphagia
HP:0007057Poor hand-eye coordination
HP:0008762Repetitive compulsive behavior
HP:0010534Transient global amnesia
HP:0012658Abnormal brain FDG positron emission tomography
HP:0031249Parageusia
HP:0034004Parosmia
HP:0100738Abnormal eating behavior
Периодический (5–29%)13
HP:0000622Blurred vision
HP:0000746Delusion
HP:0001350Slurred speech
HP:0001959Polydipsia
HP:0002018Nausea
HP:0002300Mutism
HP:0002519Hypnagogic hallucinations
HP:0004396Poor appetite
HP:0025233Sleep paralysis
HP:0030221Sweet craving
HP:0031217Hot flashes
HP:0046504Decreased libido
HP:5200218Derealization
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | — | Europe | Class only |
| Point prevalence | 1-9 / 1 000 000 | 0.18 | France | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)