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Hyperinsulinism-hyperammonemia syndrome

ORPHA:35878DiseaseAutosomal dominantInfancy, Neonatal

Ассоциированные гены (1)

GLUD1
glutamate dehydrogenase 1
Disease-causing germline mutation(s) in
OMIM: 138130

Фенотипы (12)

Очень частый (80–99%)2
HP:0008162Asymptomatic hyperammonemia
HP:0012051Reactive hypoglycemia
Частый (30–79%)10
HP:0000825Hyperinsulinemic hypoglycemia
HP:0001263Global developmental delay
HP:0001328Specific learning disability
HP:0002121Generalized non-motor (absence) seizure
HP:0002197Generalized-onset seizure
HP:0002342Intellectual disability, moderate
HP:0007018Attention deficit hyperactivity disorder
HP:0008283Fasting hyperinsulinemia
HP:0011198EEG with generalized epileptiform discharges
HP:0012402Increased urine alpha-ketoglutarate concentration

Эпидемиология (1)

Point prevalence
Unknown
Europe

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы