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Spinocerebellar ataxia type 37

ORPHA:363710DiseaseAutosomal dominantAdult

Ассоциированные гены (2)

DAB1
DAB adaptor protein 1
Disease-causing germline mutation(s) in
OMIM: 603448
SCA37
spinocerebellar ataxia 37
Disease-causing germline mutation(s) in

Фенотипы (16)

Очень частый (80–99%)3
HP:0000549Abnormal conjugate eye movement
HP:0002396Cogwheel rigidity
HP:0002527Falls
Частый (30–79%)13
HP:0000407Sensorineural hearing impairment
HP:0000666Horizontal nystagmus
HP:0001288Gait disturbance
HP:0001336Myoclonus
HP:0001337Tremor
HP:0002075Dysdiadochokinesis
HP:0002078Truncal ataxia
HP:0002167Abnormality of speech or vocalization
HP:0002168Scanning speech
HP:0002406Limb dysmetria
HP:0003474Somatic sensory dysfunction
HP:0006855Cerebellar vermis atrophy
HP:0100275Diffuse cerebellar atrophy

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы