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CADDS

ORPHA:369942DiseaseX-linked recessiveInfancy, Neonatal

Ассоциированные гены (2)

ABCD1
ATP binding cassette subfamily D member 1
Role in the phenotype of
OMIM: 300371
BCAP31
B cell receptor associated protein 31
Role in the phenotype of
OMIM: 300398

Фенотипы (17)

Очень частый (80–99%)2
HP:0001263Global developmental delay
HP:0001396Cholestasis
Частый (30–79%)6
HP:0000407Sensorineural hearing impairment
HP:0001250Seizure
HP:0001511Intrauterine growth retardation
HP:0002500Abnormal cerebral white matter morphology
HP:0030151Cholangitis
HP:0033643Increased circulating very long-chain fatty acid concentration
Периодический (5–29%)9
HP:0000347Micrognathia
HP:0000486Strabismus
HP:0000518Cataract
HP:0000835Adrenal hypoplasia
HP:0001272Cerebellar atrophy
HP:0001332Dystonia
HP:0002119Ventriculomegaly
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003196Short nose

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы