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STT3B-CDG

ORPHA:370924DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

STT3B
STT3 oligosaccharyltransferase complex catalytic subunit B
Disease-causing germline mutation(s) in
OMIM: 608605

Фенотипы (17)

Облигатный (100%)9
HP:0000252Microcephaly
HP:0001249Intellectual disability
HP:0001250Seizure
HP:0001263Global developmental delay
HP:0001272Cerebellar atrophy
HP:0001290Generalized hypotonia
HP:0001508Failure to thrive
HP:0011968Feeding difficulties
HP:0012345Abnormal glycosylation
Частый (30–79%)8
HP:0000028Cryptorchidism
HP:0000046Small scrotum
HP:0000054Micropenis
HP:0000078Abnormality of the genital system
HP:0000648Optic atrophy
HP:0001511Intrauterine growth retardation
HP:0001873Thrombocytopenia
HP:0002098Respiratory distress

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы