← Назад

Dysbetalipoproteinemia

ORPHA:412DiseaseAutosomal dominant, Multigenic/multifactorialAdolescent, Adult, Childhood, Elderly

Ассоциированные гены (1)

APOE
apolipoprotein E
Major susceptibility factor in
OMIM: 107741

Фенотипы (26)

Очень частый (80–99%)5
HP:0000951Abnormality of the skin
HP:0002155Hypertriglyceridemia
HP:0003124Hypercholesterolemia
HP:0003141Increased LDL cholesterol concentration
HP:0003233Decreased HDL cholesterol concentration
Частый (30–79%)12
HP:0000660Lipemia retinalis
HP:0000819Diabetes mellitus
HP:0001013Eruptive xanthomas
HP:0001084Corneal arcus
HP:0001114Xanthelasma
HP:0001397Hepatic steatosis
HP:0001513Obesity
HP:0002240Hepatomegaly
HP:0002635Atheromatosis
HP:0010874Tendon xanthomatosis
HP:0025530Xanthomas of the palmar creases
HP:0031290Tuberous xanthoma
Периодический (5–29%)9
HP:0000799Renal steatosis
HP:0000821Hypothyroidism
HP:0001681Angina pectoris
HP:0001735Acute pancreatitis
HP:0001997Gout
HP:0004943Accelerated atherosclerosis
HP:0004950Peripheral arterial stenosis
HP:0005181Premature coronary artery atherosclerosis
HP:0012397Aortic atherosclerosis

Эпидемиология (2)

Point prevalence
1-9 / 100 000
Europe
Point prevalence
1-5 / 10 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы