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Neonatal severe primary hyperparathyroidism

ORPHA:417DiseaseAutosomal recessive, Not applicableNeonatal

Ассоциированные гены (2)

TRPV6
transient receptor potential cation channel subfamily V member 6
Disease-causing germline mutation(s) in
OMIM: 606680
CASR
calcium sensing receptor
Disease-causing germline mutation(s) (loss of function) in
OMIM: 601199

Фенотипы (10)

Очень частый (80–99%)10
HP:0000774Narrow chest
HP:0000944Abnormal metaphysis morphology
HP:0002240Hepatomegaly
HP:0002757Recurrent fractures
HP:0100530Abnormality of calcium-phosphate metabolism
HP:0000820Abnormality of the thyroid gland
HP:0001252Hypotonia
HP:0001744Splenomegaly
HP:0003355Aminoaciduria
HP:0004322Short stature

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы