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Bietti crystalline dystrophy

ORPHA:41751DiseaseAutosomal recessiveAdolescent, Adult

Ассоциированные гены (1)

CYP4V2
cytochrome P450 family 4 subfamily V member 2
Disease-causing germline mutation(s) in
OMIM: 608614

Фенотипы (19)

Частый (30–79%)9
HP:0000505Visual impairment
HP:0000654Decreased light- and dark-adapted electroretinogram amplitude
HP:0000662Nyctalopia
HP:0001133Constriction of peripheral visual field
HP:0007722Retinal pigment epithelial atrophy
HP:0007760Crystalline corneal dystrophy
HP:0030491Choriocapillaris atrophy
HP:0031528Subretinal deposits
HP:0200065Chorioretinal degeneration
Периодический (5–29%)10
HP:0000551Color vision defect
HP:0000580Pigmentary retinopathy
HP:0000603Central scotoma
HP:0000618Blindness
HP:0001129Large central visual field defect
HP:0001141Severely reduced visual acuity
HP:0007814Retinal pigment epithelial mottling
HP:0011505Cystoid macular edema
HP:0030329Retinal thinning
HP:0030528Paracentral scotoma

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы