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COG2-CDG

ORPHA:435934DiseaseAutosomal recessiveInfancy

Ассоциированные гены (1)

COG2
component of oligomeric golgi complex 2
Disease-causing germline mutation(s) (loss of function) in
OMIM: 606974

Фенотипы (13)

Частый (30–79%)13
HP:0001249Intellectual disability
HP:0001410Decreased liver function
HP:0001999Abnormal facial shape
HP:0002079Hypoplasia of the corpus callosum
HP:0002361Psychomotor deterioration
HP:0002506Diffuse cerebral atrophy
HP:0002510Spastic tetraplegia
HP:0003256Abnormality of the coagulation cascade
HP:0005484Secondary microcephaly
HP:0010818Generalized tonic seizure
HP:0010837Decreased circulating ceruloplasmin concentration
HP:0011967Decreased circulating copper concentration
HP:0012506Small pituitary gland

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы