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X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome

ORPHA:435938Malformation syndromeX-linked recessiveAntenatal, Neonatal

Ассоциированные гены (1)

RPL10
ribosomal protein L10
Disease-causing germline mutation(s) (loss of function) in
OMIM: 312173

Фенотипы (25)

Облигатный (100%)9
HP:0000028Cryptorchidism
HP:0000252Microcephaly
HP:0000303Mandibular prognathia
HP:0001250Seizure
HP:0001252Hypotonia
HP:0001999Abnormal facial shape
HP:0002020Gastroesophageal reflux
HP:0002719Recurrent infections
HP:0008850Severe postnatal growth retardation
Частый (30–79%)16
HP:0000219Thin upper lip vermilion
HP:0000047Hypospadias
HP:0000407Sensorineural hearing impairment
HP:0000411Protruding ear
HP:0000678Dental crowding
HP:0000954Single transverse palmar crease
HP:0001182Tapered finger
HP:0001601Laryngomalacia
HP:0004415Pulmonary artery stenosis
HP:0006101Finger syndactyly
HP:0006380Knee flexion contracture
HP:0006466Ankle flexion contracture
HP:0009796Branchial cyst
HP:0012033Sacral lipoma
HP:0012385Camptodactyly
HP:0100716Self-injurious behavior

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы